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Researchers at UT Arlington have discovered a key enzyme, #IDO1, that when blocked, helps #immune cells regain their ability to properly process #cholesterol—something that breaks down during #inflammation. This breakthrough could offer a powerful new way to fight #heartdisease, #diabetes, #cancer, and more.
Researchers at UT Arlington have discovered a key enzyme, IDO1, that when blocked, helps immune cells regain their ability to properly process cholesterol—something that breaks down during inflammation.
Support our work: https://democracynow.org/donate/sm-desc-ytIn an effort to fulfill the Trump administration's daily immigration arrest "quotas," federal age...
(as personally meaningful as it was for me to experience the Cubs winning the 2016 world series) I absolutely hate this fucking timeline, must keep trusting (& working for) it being the last gasp of kyriarchy before we usher in the next chapter of better things, may it come speedily and in our days.
(the Cubs thing was a joke, sort of, don't say you don't also secretly believe it opened the gate to Hellmouth) There's a quote many of us know from Ursula K. Le Guin (about the divine right of kings) that feels really apt to me these days. I'll share it below in a sec.
I will note that what people do not always know is that she gave that speech accepting The National Book Foundation Medal for Distinguished Contribution to American Letters. And that it was part of a larger callout to the book industry. This matters. I'm going to make a point in a second.
So, the quote-- Think about where we are in history. “We live in capitalism. Its power seems inescapable. So did the divine right of kings. Any human power can be resisted and changed by human beings. Resistance and change often begin in art, and very often in our art, the art of words.”
The divine right of kings ended because human beings did things. In a bunch of places. Because things got so bad that that's what had to happen. How that happened, how that change happened, went differently in different places. There's not one answer.
(OK,a lot of monarchies ended via bloody revolution.) But we also have data on some things now that might be useful. Just saying: What is now is not what must be. And we can be the people that bring that into being. I don't know what the next chapter is, but we could be the ones to make it up.
We could be the people to bring into being the next chapter of whatever happens, which could be better than the one in which we are currently. This is possible. If we organize and bring it into being. I believe this. Do you? Another world is possible.
In any case, back to the great Ms. Le Guin. It's 2014. She was accepting a lifetime achievement award from one of the major organizations-- this was a bfd -- & she used it to call out the industry, to remind them that the work was about art, not profit.
"Hard times are coming, when we’ll be wanting voices of writers who can see alternatives to how we live now, can see through our fear-stricken society and its obsessive technologies to other ways of being, & imagine grounds for hope." She went AT them for focusing on the bottom line.
You can read the whole thing here. ❤️🔥 NOTE: at a moment when everyone was comfortable, when she could have said thank you and had everyone feel great about her, she said the hard thing. She was willing to be unpopular, to be the buzzkill, to tell them that THEY, THE CAPITALISTS, COULD BE TOPPLED--
Because she knew, as Heschel would put it, that the "hour called for moral grandeur and spiritual audacity. Because sometimes you gotta do the hard thing even if it's gonna make you unpopular, if people are gonna get mad at you, if you're gonna lose some clout or favors or whatever as a result.
Because it matters what we say, how we spend our opportunities, what stands we take. Because of that quote--how many times have you heard it repeated? How many of us can envision something on the other side of now as a result? Because of those words, that speech? That stand?
And more to the point: How many people actually heard her, for real, that night? If it was one, she did her job. If one publishing industry professional with any ounce of influence, current or future, *heard* her in that room? It was worth it for that. And even if not? Better she said it, no?
We must be brave. Those of us with any anything to spend, we gotta spend it NOW. The hour is now. How can we leverage our time, our talents, our access, opportunities, skills? What's your role in meeting this moment? Because while everyone's answer will be different, nobody's can be "nothing."
This isn't -- can you hear the people sing? OK. A lot of people are going to suffer now. A lot of people are going to die because Trump & these goons are opening literal concentration camps now, pulling healthcare, actively persecuting. Never again is now.
And I'm not saying I think I personally am gonna see what's on the other side or what, right? None of us know what is to come or when or anything. But what I'm saying is that I think we're at that time when history is pushing against us and we, us, now, can be the ones to push back.
I don't know what that looks like, exactly, except that the same things are always true-- relationships are the core unite of changemaking, as @zteutsch.bsky.social puts it. grassroots organizing is always the way. We gotta build coalitions, build movements, build things that grow and last.
This "we're all gonna come out that one time to that march that one day" is not going to free us from this. But that many people, engaged in sustained discipline of some sort over time? That many people with the bravery of Ms. Ursula Le Guin? And the more people, the less brave you have to be.
CIA Director John Ratcliffe announced Wednesday that a new CIA report reveals former FBI Director James Comey, CIA Director John Brennan, and DNI James Clapper worked together to purposely corrupt the Trump-Russia investigation in 2016 before Trump entered office.
CIA Director John Ratcliffe announced Wednesday that a new CIA report reveals former FBI Director James Comey, CIA Director John Brennan, and DNI James Clapper worked together to purposely corrupt the Trump-Russia investigation in 2016 befo…
Why is Redis just the absolute best glue between processes? Surely Linux/Unix has something just as good? But in my experience, there's literally nothing better for communicating between processes.
Don't get me wrong, I love Redis, but I just wonder why the best solution ended up being a memory based database and not something in the operating system itself.
If you ever are talking to a cop and they start fidgeting / clasping their hands like this guy is on the bodycam, tread very carefully. m.youtube.com/watch?v=HYnWsYxb…
On August 9th, 2024, officers were dispatched to Target in response to an ongoing shoplifting incident. The loss prevention officer informed them that a woma...
So fucking funny. On my way home from @pluralistic book signing do and the train has no staff, because it’s been enshittified, the burger I just eat, had to be ordered through a terminal, because ordering a fucking burger is now enshittified. Seriously just the worst timeline.
A California jury has ordered Google to pay $314.6 million to Android smartphone users in the state after finding the company liable for collecting data from idle devices without permission.
Over 80% of farmers are concerned about the impact of climate change on their ability to make a living, as more than four fifths say extreme weather has hit their productivity
who the fuck even does reaction videos anymore? where the fuck were they in the mid 2010s when every goddamn talentless nigger on youtube was becoming a reaction channel
When Microsoft locked an ICC prosecutor out of their email, it proved just how easily U.S. power can reach across borders and into the heart of global justice, writes Paul Budde.
THE RECENT INCIDENT involving Microsoft and the International Criminal Court (ICC) should send a chill down the spine of every democratic nation. Following a sanctions order from White House, Microsoft locked ICC Prosecutor Karim Khan out of his enterprise-level Office 365 account. That account wasn’t personal — it was part of the ICC’s institutional infrastructure.
And just like that, an American tech giant disabled access to a key international legal actor.
...
What’s worse is the normalisation of it all. We scroll past headlines like “Microsoft cuts #ICC access” and carry on with our day. The sociologist Alexei Yurchak coined a term for this: hypernormalisation — the idea that everyone knows the system is broken, but we all pretend things are normal because no one can imagine how to change them..."
When Microsoft locked an ICC prosecutor out of their email, it proved just how easily U.S. power can reach across borders and into the heart of global justice.
I've been keeping up on updates but I don't see much difference. Every once in a while I check up on the golang based competition to see if it's production ready.
Bill Pulte, who leads the Federal Housing Finance Agency, called on Congress to investigate Federal Reserve Chair Jerome Powell, alleging that his recent testimony to the Senate about the central bank’s planned renovations to its headquarters was “de…
I refuse to take seriously the idea that even one single person sincerely feels threatened by “death to the IDF”. You don’t. You do not. You’re pretending. You’re just victim-LARPing again.
July 2, 1863, was Day 2 of the Battle of Gettysburg. The day saw 150,000 troops locked in combat across a four-mile front. From Little Round Top to Culp’s Hill, the clashes on day 2 of the battle—Devil’s Den, the Wheatfield, Peach Orchard, and Cemetery Hill—saw over 20,000 casualties. Lee’s Confederates sought to break Meade’s fishhook line, while the Union fought to hold the high ground, pushing both armies to the brink.
At dawn on July 2, 1863, Meade’s 90,000-strong Union Army fortified Cemetery Hill, Culp’s Hill, and Cemetery Ridge, forming a defensive fishhook. Reinforced by II, V, and XII Corps, Meade prepared to repel Lee’s next strike. Across the field, Lee’s 70,000 Confederates held Seminary Ridge and Gettysburg, with Longstreet’s and Hill’s corps west, Ewell’s north. Lee planned a double assault: Longstreet to hit the Union left, Ewell the right, aiming to collapse Meade’s line.
Delays in Confederate positioning, especially Longstreet’s march, postponed attacks until afternoon, setting up a ferocious clash. Around 4:00 PM, Lt. Gen. James Longstreet’s First Corps launched Lee’s main attack on the Union left. Hood’s division, over 7,000 men, targeted III Corps under Maj. Gen. Daniel Sickles, who had advanced to a vulnerable salient at the Peach Orchard, leaving Devil’s Den exposed.
Hood’s brigades—Law’s Alabamians and Robertson’s Texans—stormed Devil’s Den, clashing with Birney’s division in a brutal fight among massive boulders. Artillery roared, while sharpshooters picked off officers. The Confederate push aimed to outflank the Union line, threatening Little Round Top and the entire Union position. By 4:30 PM, the Wheatfield, a 20-acre clearing south of the Peach Orchard, became a slaughterhouse.
Hood’s and McLaws’ Confederate brigades, including Anderson’s and Semmes’, collided with Union III Corps’ reinforcements, like de Trobriand’s brigade. Around 5:00 PM, Barnes’ V Corps division and Caldwell’s II Corps division joined the fight, turning the field into a seesaw of charges and countercharges. Regiments like the 17th Maine and 1st Minnesota fought ferociously, but Confederate pressure surged.
By 6:30 PM, after six major assaults, the Confederates held the blood-soaked Wheatfield.
At the peach orchard along the Emmitsburg Road, McLaws’ Confederate division targeted Sickles’ III Corps. Barksdale’s Mississippians and Kershaw’s South Carolinians charged, shattering Graham’s brigade with rifle volleys and cannon fire. By 6:00 PM, Hill’s corps, including Anderson’s division, joined, overwhelming Humphreys’ Union line.
Sickles’ corps crumbled, with Sickles wounded and his men retreating toward Cemetery Ridge. The collapse exposed the Union center, but Confederate momentum slowed, unable to exploit the breach fully as dusk approached.
As Devil’s Den fell, Hood’s Confederates eyed Little Round Top, which was key to the Union left. Col. Strong Vincent’s brigade, including Col. Joshua L. Chamberlain’s 20th Maine, raced to hold the hill.
Law’s Alabamians and Robertson’s Texans were met with fierce fire from the Union forces as they charged repeatedly. The 20th Maine, at the line’s end, repelled assaults, with Chamberlain’s bayonet charge breaking the Confederate push. Reinforced by Weed’s brigade, the Union held Little Round Top by dusk, saving Meade’s flank but losing Vincent and in their desperate stand.
As evening arrived, Lt. Gen. Richard S. Ewell’s Second Corps struck the Union right. Johnson’s division attacked Culp’s Hill, clashing with XII Corps under Greene. The entrenched Union troops repelled Confederate charges. Simultaneously, Early’s brigades, Hays’ and Avery’s, hit Cemetery Hill, briefly seizing XI Corps’ guns. Hancock’s II Corps counterattacked, driving the Confederates back by 9:00 PM. The Union right held firm, thwarting Lee’s plan to collapse Meade’s line.
The day saw over 20,000 casualties—roughly 10,000 per side. Union resilience, from Chamberlain’s stand to Greene’s defense, preserved Meade’s line. Lee’s near-successes emboldened him, while Meade’s army, battered but intact, braced for another Confederate onslaught the next day. July 2, was Gettysburg’s bloodiest day, with savage fighting in the Wheatfield, Devil’s Den, Peach Orchard, Little Round Top, and Culp’s Hill.
Lee’s plan to crush Meade’s flanks failed against heroic stands by the Union forces, though the Confederates came agonizingly close to victory. Both armies suffered crippling losses, yet neither yielded. As night fell, Meade fortified his fishhook, anticipating Lee’s next move. Lee, believing the Union center vulnerable, planned a massive assault for July 3 as the war’s turning point loomed, setting up Gettysburg’s final day.
And people told me I was overreacting in comparing the concentration camp to Auschwitz. They're not being subtle about what they want to do RE: bsky.app/profile/did:plc:f6s2m…
If you think all bread is created equal, think again. In Don’t Buy Bread From These 6 Brands (It’s Not What You Think), we reveal the surprising truth about ...
Victor Davis Hanson: The Trump Deranged “Experts” Were Wrong. Again.
President Donald Trump’s track record flies in the face of conventional wisdom from so-called “experts”— but they will be the last to admit it.
Since his second inauguration, the “experts” have been relentless in their mission to minimize the Trump administration’s efforts with the economy, immigration, Iran, and beyond.
Meanwhile, the stock market has soared. There were ZERO illegal border crossings in May, according to CBP. Iran’s nuclear infrastructure was left severely damaged without the threat of war on the horizon. All this, thanks to the decisive and, at times controversial, actions taken by the Trump administration.
Despite these verifiable results, @VDHanson argues that much of the elite resistance to Trump stems not from data, but from disdain. And that bias has blinded them to basic common sense. He breaks it down on this episode of “Victor Davis Hanson: In His Own Words.”
“Donald Trump is pretty commonsensical. If you take a million people away that were working in the shadows at cheaper wages and hurting American job opportunities and you make countries that had asymmetrical tariffs and were responsible for a $1.1 trillion trade deficit and you can stop that and they still want entry into the American market, then you can have an economic renaissance.
“You should try to shed your Trump Derangement Syndrome because it's really affecting your powers of judgment and analysis. And you're going to lose readers. You are so wedded to the idea that Donald Trump is going to destroy the United States because of your personal animus, you cannot see that most people have commonsense solutions.”
👉Don’t miss out on Victor’s latest videos by subscribing to The Daily Signal today. You’ll be notified every time a new piece of content drops: youtube.com/dailysignal?sub_co… 👉If you can’t get enough of Victor Davis Hanson from The Daily Signal, subscribe to his official YouTube channel: youtube.com/victordavishanson7… 👉He’s also the host of “The Victor Davis Hanson Show,” available wherever you prefer to watch or listen. Links to the show and exclusive content are available on his website: victorhanson.comminds.com/newsfeed/17872576524…
Has the Military Lost Middle America VDH’s Blade of Perseus // Private Papers Traditionalist and conservative America once was the U.S. military’s greatest defender. Bipartisan conservatives in Congress ensured generous Pentagon budgets.
Palestinians did not choose a life of war and occupation. But since this life was forced on them, they have no choice but to survive — and resist. mondoweiss.net/2025/07/palesti…
EXCLUSIVE: The twisted past of Idaho shooter Wess Roley, a rent-dodging Holocaust denier expelled from high school for terrorizing classmates dailymail.co.uk/news/article-1…
Idaho gunman Wess Roley, 20, who killed two firefighters, spread Nazi propaganda, bullied classmates, and skipped rent, his ex-roommate told DailyMail.com
California would be the biggest winner in the sanctuary vote scam, as it would gain 11 more congressional seats due to immigrants and their young children being counted in the census.
I am very pleased to announce the nomination of Eric Tung to serve as Judge on the United States Court of Appeals for the Ninth Circuit. Eric worked for two of our Country’s Greatest Supreme Court Justices, Antonin Scalia and Neil Gorsuch, before working at the Department of Justice, and serving as an Assistant U.S. Attorney for the Central District of California. Eric is a Tough Patriot, who will uphold the Rule of Law in the most RADICAL, Leftist States like California, Oregon, and Washington. It is critical now, more than ever before, that we have LAW AND ORDER. Good luck and congratulations Eric!
It is my Great Honor to nominate Joshua D. Dunlap, of the Great State of Maine, to serve as a Judge on the United States Court of Appeals for the First Circuit. Joshua is a seasoned litigator, with a TON of excellent experience, appearing before the First Circuit, and all levels of the Federal and State Judiciary. He is a Partner at Pierce Atwood LLP in Portland, Maine, and earned his J.D. from Notre Dame. We need more TOUGH and SMART Judges on the Federal Bench, who fearlessly defend our Constitution, and Joshua will do just do that. Congratulations Joshua!
A former Palantir employee is sounding the alarm. The tech company, founded by Peter Thiel, claims they can revolutionize government systems with their AI-po...
Die miese Qualität unserer Bahn ist keine NATURkatastrophe. Es ist eine politische.
Auf dem Weg nach Düsseldorf, wo ich morgen früh live im ZDF bei „Volle Kanne“ sein werde (schaltet mal rein und postet, wie ihr es fandet!) sitze ich auf dem Boden. Keine Klimaanlage im Bordbistro, ein komplett überlasteter ICE, der ungeplant viele Fahrgäste aus anderen Zügen aufnehmen musste.
DANKE an alle, die den Laden heute am Laufen halten. Trotz Hitze. Trotz Ausfällen. Trotz politischer Vernachlässigung.
An Tagen wie heute wird wieder sichtbar, wer unsere Mobilität wirklich trägt: Die Menschen bei der Bahn – in den Zügen, an den Bahnsteigen, in Servicecentern, Leitstellen, Werkstätten und Fahrgastinformationssystemen.
Bei Temperaturen deutlich über 30 Grad, unermüdlich im Einsatz, dabei oft beschimpft und sogar bedroht. IHR seid das Rückgrat der Verkehrswende. Mein Dank, Respekt und Mitgefühl gehört immer und erst recht heute euch!
Viele Verbindungen fallen heute aus. Klimaanlagen versagen. Die Infrastruktur ist durch das Extremwetter komplett überlastet.
Das ist nicht eure Schuld, sondern das Resultat jahrzehntelanger politischer Entscheidungen. Der aktuelle Zustand ist kein Zufall – er wurde gemacht.
Jahrzehntelange Unterfinanzierung der Schiene
Priorisierung von Autobahnbau und fossilem Individualverkehr
Fehlende Redundanzen und Kapazitäten
Und jetzt: immer häufigere Extremwetterlagen, die das System ans absolute Limit bringen Das ist keine NATURkatastrophe. Es ist eine politische.
Was es braucht, ist nicht noch mehr Geduld von Mitarbeitenden und Reisenden zu fordern – sondern Druck auf die Politik. Der Bundeshaushalt gibt jedes Jahr zig Milliarden für fossile Subventionen aus – vom Dienstwagenprivileg bis zur Entfernungspauschale. Geld ist da. Was fehlt, ist der Wille.
Und hier kommt ihr ins Spiel: – Schreibt eure Abgeordneten an. – Fragt, was im Bundesverkehrsministerium wirklich Priorität hat. – Macht Druck – von unten. Denn von oben bewegt sich zu wenig.
Wir brauchen:
mehr Personal, besser bezahlt und besser geschützt
mehr Züge, mehr Redundanz, mehr Resilienz
und vor allem: eine Verkehrspolitik, die aufhört, das Auto zu vergöttern, während Menschen in überhitzten Zügen arbeiten und reisen
ch stehe an der Seite derer, die heute trotzdem da sind – und trotz allem versuchen, die Mobilität der Vielen zu ermöglichen. Und kommt mir jetzt mit keinem ABER, das hatten wir Jahrzehnte lang. Es braucht jetzt endlich das DAFÜR! Für freie Wahl der Mobilität, sichere Reisen egal womit und einen Respekt, den alle verdient haben, wie auch immer sie unterwegs sein wollen.
A Spanish member of the European Parliament said Wednesday he wants the European Commission to ban Israeli military companies from accessing EU funds, citing their potential use in the war in the Gaza Strip, Anadolu reports.
Nacho Sanchez Amor, a socialist MEP and member of the European Parliament’s Subcommittee on Human Rights, said the EU must avoid “double standards” in addressing human rights violations.
“The EU cannot fall under double standards when it comes to HumanRightsViolations & it cannot be accessory to Netanyahu genocidal actions,” Amor wrote on X, referencing Israeli Prime Minister Benjamin Netanyahu, who has pursued a war of genocide against the Palestinian population in Gaza since late 2023.
Blue states: TURN YOUR AC THERMOSTAT UP THE POWER GRID IS STRUGGLING Also blue states: WE'RE BANNING COMBUSTION ENGINES JUDT GET ELECTRIC CARS AND EQUIPMENT
Miss Moonshine Buckdancer joins in on 12"x12" dance board (too small for a fast tune!) Erica Weiss guitar. Humpback Mule is a Midwestern fiddle tune. Grace i...
>have an sdcard that I used on my wiiu, but I now use a higher‐capacity card there >want to use the old card on the shitch instead >for some reason I do not just make a new filesystem >put it into the shitch and download some games >it quickly fills up even though I didn't download that many games >“delete” the files that I used on the wiiu that I don't need anymore using troonix mint's included file manager >it doesn't make much difference >the shitch doesn't display anywhere the total usage that the shitch manages or even the filesystem's capacity >decide that the card must have pretty low capacity >today I do df -h on that card >it says something like 170GiB in use >do du -sh Nintendo/ >it says something like 50GiB >do ls -a >there's a directory named .Trash-1000 >like 110GiB according to du -sh >this niggerware file manager never deleted the files
Halkın davası politikacıların taktiklerine bırakıldığında, bu dava her zaman bir maskaralığa dönüşür. Özgūr ol.mak için yönetilmek isteyen bir halk, ya aldanmaktadır ya da özgürlüğe layık değildir.
Had another song by Jack Ingram that really was a good heart string tugger so did a search and ran across this song and really like it. And it is an ultra-crisp recording to boot.
Green sweatshirt guy (Chibi) inviting himself on the couch while mustache guy (CavemanDCJ) is doing a speedrun. That day was Chibi's birthday.Full stream: ht...
Could Jay-Z be next?!BECOME A MEMBER:https://www.youtube.com/channel/UCLdP3jmBYe9lAZQbY6OSYjw/joinFOLLOW OUR NEW CHANNELS:Benny On The Block: https://www.you...
![FIREWORKS AREN'T FUN FOR EVERYONE
WILDLIFE CAN...
- die from the stress of loud noises
- abandon their babies/nest in fear
- get sick & even die from ingesting parts of fireworks
AND
- it can cause panic attacks for companion animals and trigger PTSD in humans.
[Logo for the Florida Wildlife Hospital]](https://friendica.eskimo.com/photo/preview/640/7865715 "FIREWORKS AREN'T FUN FOR EVERYONE
WILDLIFE CAN...
- die from the stress of loud noises
- abandon their babies/nest in fear
- get sick & even die from ingesting parts of fireworks
AND
- it can cause panic attacks for companion animals and trigger PTSD in humans.
[Logo for the Florida Wildlife Hospital]")
DarkMahesvara
in reply to LolikingSama • • •