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Narco-Reich or How Germany Lost the War on Drug Trafficking and Became the Epicenter of Europe’s Drug Crisis restmedia.io/narco-reich-germa…

Narco-Reich or How Germany Lost the War on Drug Trafficking and Became the Epicenter of Europe's Drug Crisis - REST

In February 2021, customs officers in Hamburg’s sprawling container port discovered 16 tons of cocaine hidden in shipping containers from Paraguay—Europe’s largest seizure to that date, worth €1.5-3.5 billion on the street.
Rest (REST)

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Editor’s Note: This article was updated Aug. 20, 2025, to correct the number of years of training data used and the model accuracy. The original article said the model was trained on 14 years of Solar Dynamics Observatory data and surpassed existing benchmarks by 15%; the model was actually trained on 9 years of data and […]

NASA, IBM’s ‘Hot’ New AI Model Unlocks Secrets of Sun

Editor's Note: This article was updated Aug. 20, 2025, to correct the number of years of training data used and the model accuracy. The original article said
Derek Koehl (NASA Science)
Unknown parent

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Alain MICHEL 🤓

@olberger
Malheureusement non. Je l'avais vue passer il y a plus d'un an, puis enregistrée dans mon ordi, mais j'ai oublié de noter la réf. et maintenant je ne sais plus où je l'avais trouvée…
😖
En tout cas, cette image a été utilisée à toutes les sauces depuis des année :
imgur.com/gallery/never-played…

reddit.com/r/Steam/comments/tj…

reddit.com/r/PoliticalHumor/co…

imgur.com/gallery/this-was-exp…

thechive.com/wp-content/upload…

Les premières images de ce type remontent à 2018 :
tineye.com/search/3e78943a0828…

Never played Fallout 76. Starfield is ok.

Discover topics like fallout, video games, uplifting, and the magic of the internet at Imgur, a community powered entertainment destination.
Imgur

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In leaked comments, the former head of Israel’s Military Intelligence said it is necessary for Israel to carry out a genocide in Gaza: “The fact that there are already 50,000 killed in Gaza is necessary and required for future generations."

mondoweiss.net/2025/08/in-leak…

#Palestine #Israel #Gaza
@palestine @israel


In leaked audio, ex-Israeli military intel chief justifies killing tens of thousands in Gaza -’

In leaked comments, the former head of Israel’s Military Intelligence said it is necessary for Israel to carry out a genocide in Gaza: “The fact that there are already 50,000 killed in Gaza is necessary and required for future generations.”
Adam Horowitz (Mondoweiss)

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Recent investigative findings have brought to light significant concerns regarding the approval and trial processes of mental health medications. Between 2013 and 2024, the U.S. Food and Drug Administration (FDA) approved 16 novel psychiatric drugs. However, the underlying clinical trials that supported these approvals show a mixed record of success and rigor. Out of 73 clinical trials for these drugs, approximately 62% were judged positive by the FDA, but some drugs were approved despite more failed or negative trials than successful ones. For instance, brexipiprazole, pimavanserin, and gepirone had fewer than half of their submitted efficacy trials deemed positive, with one even overturned by higher FDA leadership after initial rejection by medical reviewers. Notably, three drugs were approved based on a single pivotal trial, raising questions about the robustness of evidence required for market entry.

[1]Moreover, despite the ongoing intake of these medications by millions, the scientific understanding of how many psychiatric medications exert their effects remains limited. Most of the approved drugs operate through variations of mechanisms involving serotonin, dopamine, and norepinephrine systems, pathways known since psychiatric drug development began over half a century ago. There has been little advancement in fundamentally new mechanisms of action, although improvements in safety and tolerability have been made. This stagnation raises concerns about the innovation in psychiatric drug development when the efficacy and safety evidence supporting approval vary greatly and sometimes rely on unclear biological assumptions.[3]

[1]This situation prompts pressing questions: Why have so many mental health medications not gone through more rigorous and conclusive trials before approval? If the basic science behind these medications is not fully understood, how can we be certain that these drugs help patients in meaningful, long-term ways? Psychiatric disorders are complex illnesses with no validated biological biomarkers, making it difficult to measure treatment effects objectively. This scientific uncertainty may partially explain the reliance on clinical scales and the variability in trial outcomes.[1]

[3]Additionally, some critics argue that some clinical trials lack a true placebo group, as "placebo" groups often consist of patients withdrawn from other psychiatric medications, thus complicating interpretation of drug efficacy. Research on first-episode psychosis patients, for example, lacks placebo-controlled trials altogether, making it difficult to confirm short-term benefits conclusively.

[2]In summary, the recent disclosures about the variability and limitations in trials preceding FDA approval for mental health medications underscore an urgent need for greater transparency, rigorous scientific inquiry, and innovative approaches in psychiatric drug development. Until we clearly understand how these medications work and verify their benefits with solid evidence, patients and practitioners must ask: If these drugs were created with unknown science and incomplete trials, how exactly do they help? Why wasn't more stringent testing required before approval to ensure patient safety and effectiveness?

***

This essay aims to highlight the current concerns and calls for deeper investigation and clarity in the mental health medication approval process based on recent research and regulatory reviews. If you want, I can provide a detailed list of the specific drugs and trials mentioned in the latest studies. Would you like me to include that information?[2][3]

[1][1]( jamanetwork.com/journals/jaman… )
[2](johnhorgan.org/cross-check/the…)
[3](nature.com/articles/s41386-023…)
[4](skylandtrail.org/do-i-have-to-…)
[5]( sciencedirect.com/science/arti…)
[6](magazine.ucsf.edu/weight-loss-…)
[7](medicalrealities.com/mental-he… )
[8](nimh.nih.gov/health/topics/men…)
[9]( hcplive.com/view/5-fda-updates…)
[10]( scientificamerican.com/article… )

Do I Have to Take Medications to Manage My Mental Illness?

Questions and answers about psychiatric medications for mental illnesses like depression, bipolar, schizophrenia, and BPD.
Shannon (Skyland Trail)

mastodon - Link to source

Kotaku just posted:

Halloween: The Game Announced, Will Feature Multiplayer And Solo Story Mode

This new Halloween game is set to arrive on consoles and PC sometime in 2026
The post Halloween: The Game Announced, Will Feature Multiplayer And Solo Story Mode appeared first on Kotaku.

kotaku.com/halloween-the-game-…

#gamingNews

Header image for an article titled: Halloween: The Game Announced, Will Feature Multiplayer And Solo Story Mode

New Halloween Game Will Include Multiplayer And Story Mode

Zack Zwiezen (Kotaku)

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War of Accusations: Macron and Netanyahu Clash Over Palestinian State sputnikglobe.com/20250820/war-…

War of Accusations: Macron and Netanyahu Clash Over Palestinian State

President Emmanuel Macron earlier said that France will officially recognize a Palestinian state at a session of the UN General Assembly in New York in September
Sputnik International

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What the actual #EpsteinFiles Contain - Not the "Files" or Grand Jury Testimony
- 30 gigabytes of data/information - 100,000+ pages of evidence seized from Epstein’s homes, computers, safes.
- #Flight logs. visitor lists implicating elites.
- #FBI interviews w #victims & associates.
- #Banking #financial records tracing Epstein’s funding networks.
-Civil lawsuits, sealed depositions that name names. & yes, Trump’s name is all over them. #Jeffreyepstein #GhislaineMaxwell #sextrafficking #coverup
This entry was edited (2 weeks ago)

reshared this

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OPA maintainers and Styra employees hired by Apple

Link: blog.openpolicyagent.org/note-…
Discussion: news.ycombinator.com/item?id=4…


Note from Teemu, Tim, and Torin to the Open Policy Agent community

Note from Teemu, Tim, and Torin to the Open Policy Agent community Today we’re excited to announce that the creators of Open Policy Agent (along with many team members from Styra) have joined Apple …
Tim Hinrichs (Open Policy Agent)

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Worried by a "#reading crisis," #Denmark government will eliminate its #salestax on #books, looking to get more citizens buying them, The country's 25% tax on books is currently highest in Europe, stands in stark contrast w countries such as Britain that charge no sales tax on book purchases.
"We need to do all we can to fix this reading crisis that has unfortunately spread in recent years," eliminating sales tax on books would cost the state estimated 330 million kroner ($51 million) a year.

beSpacific reshared this.

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I am late to the party, by around 40 years.
But I have recently delved into Terry Pratchett's Discworld and although I'm only 2 books into this 41 book epic, I feel this is becoming a new obsession.
The world building in these books is wonderful. And I've never sat and giggled to myself as much when reading. These books are weird and wonderful and very silly in the best way.
Can we please appreciate Josh Kirby's original artwork for the series and how sick his designs are. The attention to detail is 🔥

#discworld #terrypratchett #thelightfantastic #readersofmastodon #joshkirby

The Light Fantastic - Terry Pratchett- Original artwork by Josh Kirby

mastodon - Link to source

Gamespot just posted:

What Does Xbox's Future Look Like As This Generation Draws To A Close?

Xbox's Design Head posted on LinkedIn about the current generation of Xbox wrapping up. That could mean a lot of things, so we can't read much into it. Given the timing though, it makes sense that Microsoft is thinking about what's next. Here's what was said, and what's happening with Microsoft's gaming division these days, to help us make sense of the ...

gamespot.com/articles/what-doe…

#gamingNews

Header image for an article titled: What Does Xbox's Future Look Like As This Generation Draws To A Close?

What Does Xbox's Future Look Like As This Generation Draws To A Close?

It's time to think about what's next for Xbox. But don't worry about the Series X suddenly expiring, either.
Eric Frederiksen (GameSpot)

mastodon - Link to source

I suppose it is finally time I posted, given that I have been floating around in the background of Mastodon like some sort of strange aetherial ghost.

I'm Holly. I work in Mental health.
Moving over to Mastodon feels like a form of self care. I will explain this more in another post.

I adore heavy music. Not always heavy in the traditional sense of the word, but anything that gives me goosebumps, whether instrumentally or lyrically profound.

I love black metal, death-metal, post-rock, post-metal, ambient, blackgaze.

In terms of gaming, I play on PS5. I am a lover of open world games, RPG's.
Currently playing Clair Obscure 🩶 (which is beautiful btw)

mastodon - Link to source
Your regular reminder that you don't need to be trans, nonbinary, or otherwise not cis to choose a new name or set of pronouns for yourself. You have the right to identify however you feel most valid. Be supportive of those around you and their choices, be gentle with yourself, and above all, be kind to everyone including you. Have a great day out there.

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Gematsu just posted:

Indian action adventure game Son of Thanjai announced for PS5, Xbox Series, and PC

India-based developer Ayelet Studio has announced Son of Thanjai, an action adventure game set in …

gematsu.com/2025/08/indian-act…

#gamingNews

Header image for an article titled: Indian action adventure game Son of Thanjai announced for PS5, Xbox Series, and PC

Indian action adventure game Son of Thanjai announced for PS5, Xbox Series, and PC - Gematsu

India-based developer Ayelet Studio has announced Son of Thanjai, an action adventure game set in 11th century South India. It will launch for PlayStation 5…
Sal Romano (Gematsu)

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uspol, star wars

Sensitive content

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#Trump has purchased @ least $103M in corporate & municipal #bonds since taking office in Jan, per ethics filings, unprecedented move 4 sitting president allows him 2 profit directly from companies, banks, local govts affected by his policies; spree included nearly 700 bond purchases #MorganStanley, #WellsFargo, #Qualcomm, #TMobile, #UnitedHealth, + municipal bonds tied to #hospitals, #airports, #schools, raising conflict-of-interest concerns = Trump’s sway over federal funding, monetary policy

beSpacific reshared this.

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🎸 #NaData de hoje, mas em 1994, a banda punk Fugazi, de Washington, tocou no Aeroanta, em SP. Independentes a sério, rejeitavam as grandes gravadoras, e não faziam clips.

O cover anexo, dos alunos de uma escola de rock, foi aplaudido pela banda, e é do sucesso Waiting Room, que também tocou nesse show em SP (foi a 9ª do set list):

youtube.com/watch?v=aIZD9WFpWZ…

Alunos da Escola do Rock, de Cleveland, no palco tocando punk rock

32 - Fugazi: Waiting Room

School of Rock Headliners & Junior Headliners Rocky River, Ohio perform at Whiskey Island in Cleveland, Ohio on August 4th 2018.
YouTube

mastodon - Link to source

NASA a federal government instituition allowed people to have a relogious meeting club for many years where religious activities were done

One day the name of Jesus was named in a description of a meeting for the event on a particular day

As soon as the name of Jesus was in the meeting description NASA tried to ban the event which they allowed all along before

bitchute.com/video/uOwgOTM15wI…

Kikes want to convert people to be religious Noahides but be anti Jesus

Kikes do proselytize


NASA forbids the name of Jesus

This is actually a story from 2016 that I wanted to make sure people knew about. I can't even count the number of Christians that I have had using NASA as proof of space and the globe when presented with contradictory evidence from the Bible.
Bitchute

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GamingBolt just posted:

Halloween is a New Asymmetrical Multiplayer Horror Game Based on the Classic 1978 Film

Along with 1-on-4 multiplayer, Halloween will also feature a single-player campaign giving players the perspective of Michael Myers.

gamingbolt.com/halloween-is-a-…

#gamingNews

Header image for an article titled: Halloween is a New Asymmetrical Multiplayer Horror Game Based on the Classic 1978 Film

Halloween is a New Asymmetrical Multiplayer Horror Game Based on the Classic 1978 Film

Joelle Daniels (GamingBolt)

mastodon - Link to source
First post on a new instance! I blame @joel for perking my interest in the modern Solaris variants. I also have a tendency to self flagellate with SPARC based hardware and I wonder if these to great tastes taste great together.. Anyway, excited to be here despite my utter lack of practical experience with these variants!

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It's Zelda Time! I'm playing A Link to the Past for the first time even, on day 10(!!!) of the All-Retro Subathon!

🐰✨ twitch.tv/bunnyhearted/
vt.social/users/bunnyhearted/s…


BunnyHearted - Twitch

HYAH! Hyaaah! [SNES - Zelda: Link to the Past] All-Retro subathon, Day 10! ૮ ˶ᵔ ᵕ ᵔ˶ ა !retro !q&a // !bds 🏳️‍⚧️🍉✊
Twitch

Bunny Hearted

2025-08-20 13:21:54

mastodon - Link to source

💫 The all-retro subathon returns, with Day 10!!

Today plants and pottery better be on guard: 'cause I'm playing The Legend of Zelda: A Link to the Past for the very first time! Hyah! Kablooie! 🗡️🧝

Streams up at 2et (~5hrs) 🐰💕 #vtuber #retrogaming

With a starry purple and blue background, the words "Bunnyhearted's incredibly belated birthday 100% retro gamin' subathon!". Shows stats for today, as: day 10, timer: 31:12:50, spicy jellybeans: 110 (23 owing), Next unlock: Retro Horror Games Day! Below that is a little moon and the words "In this episode": The Legend of Zelda: A Link to the Past! Shows stream times of 11am pt, 2pm et, and 6pm utc. Also some retro sprites (link, a fairy, and a metroid) are there in the corner, by a shocked and rounded bunny (who is a white retro anime bunnygirl with brown floofy hair and glasses).

mastodon - Link to source

IGN just posted:

Spider-Verse Filmmakers Lord and Miller Are Making an Archie Comics Movie

Phil Lord and Christopher Miller, the famous filmmaking pair known for Cloudy With a Chance of Meatballs, The Lego Movie, 21 Jump Street, The Mitchells vs. the Machines, and the Spider-Verse films, are about to tackle a new, unexpected project. They're making a film based on Archie comics.

ign.com/articles/spider-verse-…

#gamingNews

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Spider-Verse Filmmakers Lord and Miller Are Making an Archie Comics Movie - IGN

Rebekah Valentine (IGN)

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Delu-san dazo!
Gelbooru LinkSource

appleseed (appleseed art), delutaya, delruki, indie virtual youtuber, nike (company), bad id, bad pixiv id, highres, 1girl, diagonal bangs, earrings, fang, full body, gold earrings, green hair, hair ornament, hood, hoodie, jewelry, leggings, open mouth, r

Browse millions of anime, manga, videos, hentai, and video game themed images on Gelbooru. Discover art with detailed tags. Contains explicit hentai content.
Gelbooru

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Adult oriented clubbing outfit

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