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in reply to Cozy Clew

pleroma - Link to source

Grumblesock

@CozyLife I am hoping to sleep better tonight. I had serotonin shock going on for hours in the small hours of the morning. Very annoying night, I have made the bed with my favourite clean sheets and shall shower before getting into bed, so that I'm clean and unwound and hopefully out like a light. 😁
in reply to atomic

mastodon - Link to source

shortstories

This is yet another example of my point that statistical significance testing has ruined science

So if someone has a thick neck because their neck is full of fat they will most likely not live as long

But if someone has a thick neck because their neck is strong and muscular that can protect them from a lot of injuries

side note

A higher butt to waist circumfrence ratio is also believed to indicate a lower heart attack risk

Only this study you linked looks at neck circumfrence

mastodon - Link to source

CNN’s Abby Phillip responds to Trump’s attempts to downplay slavery | CNN Politics – DrWeb's Domain

drwebdomain.blog/2025/08/20/cn…


CNN’s Abby Phillip responds to Trump’s attempts to downplay slavery | CNN Politics

President Trump says one of the reasons for his crackdown on Smithsonian museums is “everything discussed is how bad slavery was.” Abby Phillip and the CNN NewsNight panel discuss this …
DrWeb's Domain
in reply to Fou

mastodon - Link to source

SecretS

@foufoutos αυτός το αποτέλεμα θέλει & ας μη σε ενθουσιάζει το ζητούμενο του είναι να το παίξει “σωστά” το σύστημα του όσο μπορεί & δε χρειάζεται & αρκετός κόπος με τα χαϊβάνια που έχουμε μπλέξει & καταλαβαίνεις εμείς & κάποιοι ακόμη μπορεί να τον βρίζουμε αλλά το 41% μην πω & παραπάνω πάλι μούσκεμα θα γίνει από τον ενθουσιασμό του. Κάτι έλεγες για δημοκρατικές & ανθρώπινες αξίες? 😛

mastodon - Link to source

We have over 80 who are entirely eligible to come to U.K. We need Home Office to treat students equitably. The horror and devastation from those with scholarships but not under FCDO selection but under Home Office is overwhelming for everyone involved. We need consistent, equitable decision making.

theguardian.com/education/2025…


UK to evacuate nine Gaza students with university scholarships

Move follows months of pressure from MPs, academics and campaigners, with dozens of other students still stranded
Sally Weale (The Guardian)

mastodon - Link to source

Gematsu just posted:

Styx: Blades of Greed ‘Gameplay Reveal’ trailer

Publisher Nacon and developer Cyanide Studio have released the gameplay reveal trailer for stealth action …

gematsu.com/2025/08/styx-blade…

#gamingNews

Header image for an article titled: Styx: Blades of Greed ‘Gameplay Reveal’ trailer

Styx: Blades of Greed ‘Gameplay Reveal’ trailer - Gematsu

Publisher Nacon and developer Cyanide Studio have released the gameplay reveal trailer for stealth action game sequel Styx: Blades of Greed. Here is an overview…
Sal Romano (Gematsu)

mastodon - Link to source

Je suis en train de tester un #Garmin Edge 540.

Et bon sang, quelle sombre merde !

Désolé, mais ça fait littéralement deux heures que je tente de comprendre comment faire des trucs basiques comme : afficher simplement ma vitesse et la carte de l’endroit !

Mais, je suis dans des menus qui n’ont aucune logique, le truc bippe tout le temps sans m’expliquer la raison, il me propose sans arrèt du Garmin Coaching.

C’est littéralement hallucinant que ce truc se vende.

Unknown parent

mastodon - Link to source

ploum

@niavy : non, juste que Komoot m’a dit que je devais passer à Premium si je voulais utiliser le guidage Komoot plutôt que le guidage Garmin.

Le guidage Komoot est beaucoup plus intuitif à lancer/utiliser et, d’après les captures d’écran, semble plus lisible (mais je n’ai pas Premium)

mastodon - Link to source

قسمت چهاردهم: آخر ماجرا
enlacezapatista.ezln.org.mx/20…

"قسمت چهاردهم: آخر ماجرا آن بالاها ماه، بالاخره با خیال راحت، لبخند می‌زند. دخترکی خواب می‌بیند. خواب می‌بیند که […]"


قسمت چهاردهم: آخر ماجرا

قسمت چهاردهم: آخر ماجرا   آن بالاها ماه، بالاخره با خیال راحت، لبخند می‌زند. دخترکی خواب می‌بیند. خواب می‌بیند که با بچه‌های دیگری دنبال توپ می‌دود؛ نه برای فرار از بمب و تیر، بلکه برای تصویر …
Enlace Zapatista

misskey - Link to source
Pixel 10のSoC「Tensor G5」は過去最大の性能向上。Qi 2対応で充電も便利に - PC WatchPixelは安価（コスパが良い）だったから良い選択肢になっていましたがここまで価格が上がってくると本当に性能に見合った価値があるかはちょっと​:kumapu_hatena:​ではあります
ここまで来ると素直に他者の方がコスパ良さそうな気がしてしまっていて

Pixel 10のSoC「Tensor G5」は過去最大の性能向上。Qi 2対応で充電も便利に

　米Googleは8月21日、スマートフォン「Google Pixel 10」シリーズを発表、予約販売を開始した。価格はPixel 10が12万8,900円から、Pixel 10 Proが15万9,800円から、Pixel 10 Pro XLが19万2,900円から、Pixel 10 Pro Foldが26万7,500円からとなっており、発売はPixel 10 Pro Foldのみが10月9日で、それ以外は8月28日。
PC Watch

mastodon - Link to source

Resümee des dritten Teils des zapatistischen Beitrags auf dem Treffen der Widerstände und Rebellionen.
enlacezapatista.ezln.org.mx/20…

"Resümee des dritten Teils des zapatistischen Beitrags auf dem Treffen der Widerstände und Rebellionen. Previously Nachdem die zapatistischen Comunidades an […]"


Resümee des dritten Teils des zapatistischen Beitrags auf dem Treffen der Widerstände und Rebellionen.

Resümee des dritten Teils des zapatistischen Beitrags auf dem Treffen der Widerstände und Rebellionen. Previously Nachdem die zapatistischen Comunidades an einer Versammlung unserer Toten (erster T…
Enlace Zapatista

mastodon - Link to source

Fewer Americans read for pleasure as attention spans decline, study finds – The Washington Post – DrWeb's Domain

drwebdomain.blog/2025/08/20/fe…


Fewer Americans read for pleasure as attention spans decline, study finds – The Washington Post

Why so few Americans read for pleasure Leisure reading among U.S. adults 15 and older has dropped 40 percent in the past 20 years, according to researchers. August 20, 2025 at 11:00 a.m. EDTToday a…
DrWeb's Domain

misskey - Link to source
触ってきました「RICOH GR IV」。GR IIIからの変化点を詳しくチェック - デジカメ Watch少し重くなっているみたいでそこは少し気になりますがやっぱり欲しい​:flying_money:​

触ってきました「RICOH GR IV」。GR IIIからの変化点を詳しくチェック

リコーイメージング株式会社は8月19日（火）、2025年秋に発売予定のレンズ一体型デジタルカメラ「RICOH GR IV」の動作機を関係者向けに初公開した。外観写真を中心にハンズオンレポートをお届けする。
デジカメ Watch

misskey - Link to source
Panzer vor!
URL: pixiv.net/artworks/130028101

#ガールズ&パンツァー アヒルさんチームのパイプこうげき - 佐藤ヤスのイラスト - pixiv

パイプ攻撃とは！前衛のアタッカー(妙子)がおとりになって、後衛の選手(忍)がバックアタックを打つ攻撃。セッター(キャプテン)は妙子にAクイックを打たせると見せかけて、バックアタックに跳んできた忍へトス
pixiv

mastodon - Link to source

Gematsu just posted:

Robo Frenzy adds Xbox Series and Switch versions, launches in 2026

Side-scrolling beat ’em up game Robo Frenzy will launch for Xbox Series, Switch, and PC …

gematsu.com/2025/08/robo-frenz…

#gamingNews

Header image for an article titled: Robo Frenzy adds Xbox Series and Switch versions, launches in 2026

Robo Frenzy adds Xbox Series and Switch versions, launches in 2026 - Gematsu

Side-scrolling beat ’em up game Robo Frenzy will launch for Xbox Series, Switch, and PC via Steam in 2026, developers YummyYummyTummy and Tamatin Entertainment…
Sal Romano (Gematsu)

friendica - Link to source
Narco-Reich or How Germany Lost the War on Drug Trafficking and Became the Epicenter of Europe’s Drug Crisis restmedia.io/narco-reich-germa…

Narco-Reich or How Germany Lost the War on Drug Trafficking and Became the Epicenter of Europe's Drug Crisis - REST

In February 2021, customs officers in Hamburg’s sprawling container port discovered 16 tons of cocaine hidden in shipping containers from Paraguay—Europe’s largest seizure to that date, worth €1.5-3.5 billion on the street.
Rest (REST)

friendica - Link to source
Editor’s Note: This article was updated Aug. 20, 2025, to correct the number of years of training data used and the model accuracy. The original article said the model was trained on 14 years of Solar Dynamics Observatory data and surpassed existing benchmarks by 15%; the model was actually trained on 9 years of data and […]

NASA, IBM’s ‘Hot’ New AI Model Unlocks Secrets of Sun

Editor's Note: This article was updated Aug. 20, 2025, to correct the number of years of training data used and the model accuracy. The original article said
Derek Koehl (NASA Science)
Unknown parent

mastodon - Link to source

Alain MICHEL 🤓

@olberger
Malheureusement non. Je l'avais vue passer il y a plus d'un an, puis enregistrée dans mon ordi, mais j'ai oublié de noter la réf. et maintenant je ne sais plus où je l'avais trouvée…
😖
En tout cas, cette image a été utilisée à toutes les sauces depuis des année :
imgur.com/gallery/never-played…

reddit.com/r/Steam/comments/tj…

reddit.com/r/PoliticalHumor/co…

imgur.com/gallery/this-was-exp…

thechive.com/wp-content/upload…

Les premières images de ce type remontent à 2018 :
tineye.com/search/3e78943a0828…

Never played Fallout 76. Starfield is ok.

Discover topics like fallout, video games, uplifting, and the magic of the internet at Imgur, a community powered entertainment destination.
Imgur

mastodon - Link to source

In leaked comments, the former head of Israel’s Military Intelligence said it is necessary for Israel to carry out a genocide in Gaza: “The fact that there are already 50,000 killed in Gaza is necessary and required for future generations."

mondoweiss.net/2025/08/in-leak…

#Palestine #Israel #Gaza
@palestine @israel


In leaked audio, ex-Israeli military intel chief justifies killing tens of thousands in Gaza -’

In leaked comments, the former head of Israel’s Military Intelligence said it is necessary for Israel to carry out a genocide in Gaza: “The fact that there are already 50,000 killed in Gaza is necessary and required for future generations.”
Adam Horowitz (Mondoweiss)

Sozan reshared this.

ActivityPub - Link to source

Recent investigative findings have brought to light significant concerns regarding the approval and trial processes of mental health medications. Between 2013 and 2024, the U.S. Food and Drug Administration (FDA) approved 16 novel psychiatric drugs. However, the underlying clinical trials that supported these approvals show a mixed record of success and rigor. Out of 73 clinical trials for these drugs, approximately 62% were judged positive by the FDA, but some drugs were approved despite more failed or negative trials than successful ones. For instance, brexipiprazole, pimavanserin, and gepirone had fewer than half of their submitted efficacy trials deemed positive, with one even overturned by higher FDA leadership after initial rejection by medical reviewers. Notably, three drugs were approved based on a single pivotal trial, raising questions about the robustness of evidence required for market entry.

[1]Moreover, despite the ongoing intake of these medications by millions, the scientific understanding of how many psychiatric medications exert their effects remains limited. Most of the approved drugs operate through variations of mechanisms involving serotonin, dopamine, and norepinephrine systems, pathways known since psychiatric drug development began over half a century ago. There has been little advancement in fundamentally new mechanisms of action, although improvements in safety and tolerability have been made. This stagnation raises concerns about the innovation in psychiatric drug development when the efficacy and safety evidence supporting approval vary greatly and sometimes rely on unclear biological assumptions.[3]

[1]This situation prompts pressing questions: Why have so many mental health medications not gone through more rigorous and conclusive trials before approval? If the basic science behind these medications is not fully understood, how can we be certain that these drugs help patients in meaningful, long-term ways? Psychiatric disorders are complex illnesses with no validated biological biomarkers, making it difficult to measure treatment effects objectively. This scientific uncertainty may partially explain the reliance on clinical scales and the variability in trial outcomes.[1]

[3]Additionally, some critics argue that some clinical trials lack a true placebo group, as "placebo" groups often consist of patients withdrawn from other psychiatric medications, thus complicating interpretation of drug efficacy. Research on first-episode psychosis patients, for example, lacks placebo-controlled trials altogether, making it difficult to confirm short-term benefits conclusively.

[2]In summary, the recent disclosures about the variability and limitations in trials preceding FDA approval for mental health medications underscore an urgent need for greater transparency, rigorous scientific inquiry, and innovative approaches in psychiatric drug development. Until we clearly understand how these medications work and verify their benefits with solid evidence, patients and practitioners must ask: If these drugs were created with unknown science and incomplete trials, how exactly do they help? Why wasn't more stringent testing required before approval to ensure patient safety and effectiveness?

***

This essay aims to highlight the current concerns and calls for deeper investigation and clarity in the mental health medication approval process based on recent research and regulatory reviews. If you want, I can provide a detailed list of the specific drugs and trials mentioned in the latest studies. Would you like me to include that information?[2][3]

[1][1]( jamanetwork.com/journals/jaman… )
[2](johnhorgan.org/cross-check/the…)
[3](nature.com/articles/s41386-023…)
[4](skylandtrail.org/do-i-have-to-…)
[5]( sciencedirect.com/science/arti…)
[6](magazine.ucsf.edu/weight-loss-…)
[7](medicalrealities.com/mental-he… )
[8](nimh.nih.gov/health/topics/men…)
[9]( hcplive.com/view/5-fda-updates…)
[10]( scientificamerican.com/article… )

Do I Have to Take Medications to Manage My Mental Illness?

Questions and answers about psychiatric medications for mental illnesses like depression, bipolar, schizophrenia, and BPD.
Shannon (Skyland Trail)

mastodon - Link to source

Kotaku just posted:

Halloween: The Game Announced, Will Feature Multiplayer And Solo Story Mode

This new Halloween game is set to arrive on consoles and PC sometime in 2026
The post Halloween: The Game Announced, Will Feature Multiplayer And Solo Story Mode appeared first on Kotaku.

kotaku.com/halloween-the-game-…

#gamingNews

Header image for an article titled: Halloween: The Game Announced, Will Feature Multiplayer And Solo Story Mode

New Halloween Game Will Include Multiplayer And Story Mode

Zack Zwiezen (Kotaku)

friendica - Link to source
War of Accusations: Macron and Netanyahu Clash Over Palestinian State sputnikglobe.com/20250820/war-…

War of Accusations: Macron and Netanyahu Clash Over Palestinian State

President Emmanuel Macron earlier said that France will officially recognize a Palestinian state at a session of the UN General Assembly in New York in September
Sputnik International

mastodon - Link to source
What the actual #EpsteinFiles Contain - Not the "Files" or Grand Jury Testimony
- 30 gigabytes of data/information - 100,000+ pages of evidence seized from Epstein’s homes, computers, safes.
- #Flight logs. visitor lists implicating elites.
- #FBI interviews w #victims & associates.
- #Banking #financial records tracing Epstein’s funding networks.
-Civil lawsuits, sealed depositions that name names. & yes, Trump’s name is all over them. #Jeffreyepstein #GhislaineMaxwell #sextrafficking #coverup
This entry was edited (2 weeks ago)

reshared this

mastodon - Link to source

OPA maintainers and Styra employees hired by Apple

Link: blog.openpolicyagent.org/note-…
Discussion: news.ycombinator.com/item?id=4…


Note from Teemu, Tim, and Torin to the Open Policy Agent community

Note from Teemu, Tim, and Torin to the Open Policy Agent community Today we’re excited to announce that the creators of Open Policy Agent (along with many team members from Styra) have joined Apple …
Tim Hinrichs (Open Policy Agent)

mastodon - Link to source
Worried by a "#reading crisis," #Denmark government will eliminate its #salestax on #books, looking to get more citizens buying them, The country's 25% tax on books is currently highest in Europe, stands in stark contrast w countries such as Britain that charge no sales tax on book purchases.
"We need to do all we can to fix this reading crisis that has unfortunately spread in recent years," eliminating sales tax on books would cost the state estimated 330 million kroner ($51 million) a year.

beSpacific reshared this.

mastodon - Link to source

I am late to the party, by around 40 years.
But I have recently delved into Terry Pratchett's Discworld and although I'm only 2 books into this 41 book epic, I feel this is becoming a new obsession.
The world building in these books is wonderful. And I've never sat and giggled to myself as much when reading. These books are weird and wonderful and very silly in the best way.
Can we please appreciate Josh Kirby's original artwork for the series and how sick his designs are. The attention to detail is 🔥

#discworld #terrypratchett #thelightfantastic #readersofmastodon #joshkirby

The Light Fantastic - Terry Pratchett- Original artwork by Josh Kirby

mastodon - Link to source

Gamespot just posted:

What Does Xbox's Future Look Like As This Generation Draws To A Close?

Xbox's Design Head posted on LinkedIn about the current generation of Xbox wrapping up. That could mean a lot of things, so we can't read much into it. Given the timing though, it makes sense that Microsoft is thinking about what's next. Here's what was said, and what's happening with Microsoft's gaming division these days, to help us make sense of the ...

gamespot.com/articles/what-doe…

#gamingNews

Header image for an article titled: What Does Xbox's Future Look Like As This Generation Draws To A Close?

What Does Xbox's Future Look Like As This Generation Draws To A Close?

It's time to think about what's next for Xbox. But don't worry about the Series X suddenly expiring, either.
Eric Frederiksen (GameSpot)

mastodon - Link to source

I suppose it is finally time I posted, given that I have been floating around in the background of Mastodon like some sort of strange aetherial ghost.

I'm Holly. I work in Mental health.
Moving over to Mastodon feels like a form of self care. I will explain this more in another post.

I adore heavy music. Not always heavy in the traditional sense of the word, but anything that gives me goosebumps, whether instrumentally or lyrically profound.

I love black metal, death-metal, post-rock, post-metal, ambient, blackgaze.

In terms of gaming, I play on PS5. I am a lover of open world games, RPG's.
Currently playing Clair Obscure 🩶 (which is beautiful btw)

mastodon - Link to source
Your regular reminder that you don't need to be trans, nonbinary, or otherwise not cis to choose a new name or set of pronouns for yourself. You have the right to identify however you feel most valid. Be supportive of those around you and their choices, be gentle with yourself, and above all, be kind to everyone including you. Have a great day out there.
⇧