On Covid-19 and Vaccinations
So far there have been incidents of neurological damage with Pfiezer, Moderna, Astra-Xenica, and Johnson and Johnson vaccines.
Further, 1/3rd of people who recover from Covid-19 have some degree of neurological damage.
This leads me to believe some part of the spike protein being expressed by the virus itself and by the vaccines MUST either directly be responsible for this neurological damage or results in the immune system doing neurological damage.
There isn't much else in common with the virus itself and all four vaccines.
It seems the appropriate course of action is to determine what aspect is causing this damage and eliminate it from the vaccines before condemning more people to this damage.
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BR 549 ☎
in reply to Nanook • •I think the problem is in the spike protein itself. did no one think such a biomolecule might be toxic?
all the vaccines contain genetic code for the spike. and the Novavax does not contain an RNA molecule, but consists mostly of purified spikes. I haven't heard anything about it, perhaps it never got EUA. AFAIK a vaccine for no other disease does this --
spikes are like little spring loaded harpoons that respond to some stimulus (ACE2) and then open up and stab a little hydrophobic end into the cell membrane. after that undergoes another conformational change that pulls the viral envelope and cell membrane together, merging their contents. various other viruses do similar things -- the syncytia viruses cause neighboring host cells to stick together with such spikes.
I suspect it is the spikes doing this damage -- the vaccine does not make virus particles but just loose spikes circulating in the blood. (and blood clots can account for a lot of secondary damage)
Nanook
in reply to BR 549 ☎ • •@BR 549 ☎ I'm pretty sure this was an engineered bioweapon to start with. The spike protein strongly resembles that of the AIDS virus. Maybe gay bats, I dunno, but the fact that Fauci was working on Corona viruses at Fort Deitrich, then was denied permission to do gain of function research there so contracted a lab in Wuhan to do it, then the outbreak happens in Wuhan. Coincidence? I think not.
Now the AIDS spike protein resembled a protein on the surface of CD4 cells and that's why it kills them, actually it gets the immune system to kill itself. I wonder if perhaps there is something in the Covid-19 spike that looks like nerve tissue surface proteins.
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BR 549 ☎
in reply to Nanook • •and I'm pretty sure that viruses evolved these spikes themselves, they have had a long tome to work on them. the biologists are still pretty new to protein folding and this thing works like a mousetrap.
the clever thing the molecular biologists did was to dissect out the code for the spike and put it in the vaccine.
Nanook
in reply to BR 549 ☎ • •BR 549 ☎
in reply to Nanook • •Nanook
in reply to BR 549 ☎ • •BR 549 ☎
in reply to Nanook • •Nanook
in reply to BR 549 ☎ • •BR 549 ☎
in reply to Nanook • •in one of the less popular functions of cellular protein metabolism, defective, damaged, and mis-folded proteins are chopped into short segments by this little molecular machine. some of these segments, of 8 to 12 peptides length, are presented at the cell surface to elements of the immune system. the immune system has a memory, and a library, of these segments -- some of them are from self-proteins and some may be viral, if the cell is infected. the immune system does an amazing job of profiling each cell and tissue from these segments.
the lesson to be learned here is that the antigen does not have to be always-present at the surface of the virus. maybe the receptor binding domain is a good choice of antigen, but maybe it is not. the RBD tends to change with mutation, while many other viral proteins are 'conserved', meaning that any mutation would change their structure and render the resulting virus non-viable. some areas of the spike are also conserved, the ones making up the little springs and levers of this molecular weapon. these tend to be harder for the immune system to 'see', being down along the side of the spike and not at the tip.
I surely do not know whether there is a better epitope, but I strongly suspect that these vaccine-related clotting events have something to do with the choice. the obvious advantage of spike is that it is always present on the virus, while that protein-degrading-presenting function would only apply to infected cells after the virus gets into them.
Nanook
in reply to BR 549 ☎ • •BR 549 ☎
in reply to Nanook • •@Robert Dinse some Corona family viruses enter the cell via an endosome. it's not believed that this is a significant route in SARS-Cov2.
and, there are other considerations when choosing an epitope, other than 'spiky looking thing' ... you want something unique to the virus and distinct from most human proteins. granted, the spike probably has some of those. like you said in another comment, the spike has several potential epitopes. maybe one of them is problematic for human immune systems.
I just think that a bit more research should have been done on this.